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Morphological variation among corticothalamic terminals implies diverse function of layer 5 projections

Kevin P Koster and Briana J Carroll

forebrain circuitry, cortical laminae, neuronal properties, structure and function

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Postdocs are doing it for themselves: peer mentorship and why it matters

Peter S Myers, PhD, Catherine R Hoyt, PhD, OTD, OTR/L2

Postdoctoral training offers an opportunity to further develop as a researcher, leader, and educator and is often required to be considered competitive in one’s career path. This means that quality mentorship plays an enormous role in one’s individual success,

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A timeseries analysis of the fracture callus extracellular matrix proteome during bone fracture healing

Christopher B. Erickson, Ryan Hill, Donna Pascablo, Galateia Kazakia, Kirk Hansen, Chelsea Bahney

While most bones fully self-heal, certain diseases require bone allograft to assist with fracture healing. Bone allografts offer promise as treatments for such fractures due to their osteogenic properties.

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Bacteria: our ally in the fight against cancer

Bhavana Kushwaha and Manish Charan

Cancer heterogeneity and development of resistance is the main limiting factor for the management and treatment of the disease.

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The conflicting role of SIRT3 as therapeutic target in cancer

Patrick M. Schaefer, Devyani Bhosale

Mitochondria are increasingly recognized as key factors in cancer, affecting a multitude of tumor hallmarks. Likewise, sirtuin 3, a master regulator of mitochondrial function, has gained attention as a therapeutic target in cancer.

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RNA oxidation: Role of polynucleotide phosphorylase in the quality control of oxidized RNA

Sulochan Malla, and Alexander Kwakye

Reactive oxygen species is one of the most common cellular RNA damaging agents in living organisms. A growing number of studies show a strong correlation between oxidatively damaged RNA and human diseases, predominantly age-related neurodegenerative disorders.

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Differences in Therapeutic Efficacy in Pancreatic Cancer Between Interstitial and Superficial Light Delivery Strategies in Targeted Photo Therapy

Nzola De Magalhães

The purpose of this study was to determine if therapeutic efficacy of a Cetuximab based near-infrared (NIR) targeted photo therapy (TPT) was dependent on light delivery strategies.

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In silico screening for investigating the potential activity of phytoligands against SARS-CoV-2

Acharya Balkrishna, Pallavi Thakur, Shivam Singh, Namita Singh, Ankit Tanwar, and Rakesh Kumar Sharma

SARS-CoV-2 causes COVID-19, a life-threatening respiratory illness with high rates of morbidity and mortality. As of date, there is no specific medicine to treat COVID-19.

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Cell type resolved co-expression networks of core clock genes in brain development

Surbhi Sharma, Asgar Hussain Ansari, Soundhar Ramasamy

The circadian clock regulates vital cellular processes by adjusting the physiology of the organism to daily changes in the environment. Rhythmic transcription of core Clock Genes (CGs) and their targets regulate these processes at the cellular level.

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Drug testing and delivery techniques for the in vivo tumor spheroid based shell-less chorioallantoic membrane model

Nzola De Magalhães

We have previously published in detail our methodology of developing the novel tumor spheroid-based shell-less chicken embryo Chorioallantoic Membrane (CAM) model, and its applications in biomedical research.

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