Dr. SILVINA DEL CARMEN
 
 
First Name
SILVINA
Last Name
DEL CARMEN
University/Institution
The Jackson Laboratory
Email ID
silvina.delcarmen@jax.org
City
New Britain
Country
United States
State
Connecticut
Zip code
06032
Department
Immunology
Area of Research
Human Immunology
Area of Expertise
Mice and human immunology, microbiology
Brief Description of Research Interest:
 

During my Ph.D back in Argentina I worked with lactic acid bacteria, and studied how to use them to enhance gut immunity in mice. This spiked my interest in how our immune system works. So I decided to pursue my postdoctoral studies at Yale where I had a chance to study mechanisms that involve innate immunity and coagulation. I learned how immune cells are crucial for defending us from pathogens for example, and how they also need to maintain extreme efficiency in their functions, otherwise their mistakes can give rise to uncontrolled responses that lead to chronic autoimmune diseases. Currently I work as a postdoc at the Jackson laboratories where I am learning bioinformatic analysis and my goal is to identify potential protein targets suitable for the development of new disease biomarkers and/or immunotherapeutic strategies for an autoimmune disorder, systemic lupus erythematosus (SLE). Several studies have analyzed the levels of expression of potential biomarkers and targets for  therapies using RNA-seq, without considering the additional level of complexity introduced by the occurrence of splicing events. My hypothesis is that spliced isoforms of known activator or inhibitor receptors of the immune response regulate the aberrant immune response in SLE.

 
Representative Publications:
 

del Carmen S., Hapak S., Ghosh G., Rothlin C.V. (2018) Coagulopathies and inflammatory diseases: “...glimpse of a Snark”. Current opinion in Immunology 55:44-53

del Carmen S., Miyoshi A., Azevedo V., de Moreno de LeBlanc A., LeBlanc J.G. Evaluation of a Streptococcus thermophilus strain with innate anti- inflammatory properties as a vehicle for IL-10 cDNA delivery in an acute colitis model. (2015) Cytokine 73:177-183

del Carmen S.+, Martín R.,+, Saraiva T., Miyoshi A., Azevedo V., de Moreno de LeBlanc A., Langella P., Bermúdez-Humarán L. and LeBlanc J.G. Protective effects of lactococci strains delivering either IL-10 protein or cDNA in a TNBS- induced chronic colitis model (2014) Journal of Clinical Gastroenterology 48:S12–S17. 

del Carmen S., de Moreno de LeBlanc A., Martin R., Chain F., Kharrat P., Langella P., Bermúdez-Humarán L., LeBlanc J.G. Genetically Engineered Immunomodulatory Streptococcus thermophilus Strains Producing Antioxidant Enzymes Exhibit Enhanced Anti-Inflammatory Activities (2013) Applied and Environmental Microbiology. AEM. 80(3): 869-877.