Dr. ZHECHUN ZHANG
 
 
First Name
ZHECHUN
Last Name
ZHANG
University/Institution
Harvard University
Email ID
zhechunzhang@fas.harvard.edu
City
Cambridge
Country
United States
State
Massachusetts
Zip code
02138
Department
Molecular Cell Biology
Area of Research
Stem cell, Development, Neurodegenerative disease
Area of Expertise
Computer simulation, Human stem cells, Embryology
Brief Description of Research Interest:
 
I study the role of receptor localization in development and disease. Receptors account for ~10% of protein coding genes, and are targeted by ~50% of FDA approved drugs. Recent studies show that receptor localization can dramatically affect how tissue senses signals. I am interested in how apical/basal localization of signaling receptors controls developmental patterning and impacts drug delivery.
 
Representative Publications:
 
“Embryogeometry drives formation of robust signaling gradients through receptor localization”, Z. Zhang, S. Zwick, E. Loew, J. S. Grimley, S. Ramanathan, Nature Communication, Accepted (2019)

“Parsing the roles of neck-linker docking and tethered head diffusion in the steppingdynamics of kinesin”, Z. Zhang, Y. Goldtzvik, D. Thirumalai, Proceedings of the National Academy of Sciences 114 (46), E9838-E9845(2017)

“Dissecting the kinematics of the kines in step” Z. Zhang, D. Thirumalai, Structure 20 (4), 628-640 (2012)